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. 2021 Nov 17;19:373. doi: 10.1186/s12951-021-01123-9

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© The Author(s) 2021

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.

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Fig. 6 — Cur@EVs^−cl−NGF promotes the recovery of motor function after SCI. A Ultrastructure of myelin sheaths from different groups determined by TEM. B H&E stained images of spinal cord tissue from different groups. C Fluorescence images of spinal cord tissue, in which the green channel represented neuronal axon tubulin (β3-Tubulin) and the red channel represented astrocytes (GFAP). D Fluorescence quantitative statistical analysis of β3-Tubulin and GFAP in figure C. E Representative images of footprint behavioral assays. F Quantitative analysis of stride length and stride width in footprint assays. G Mice motor functional recovery of different groups mice during treatment using BMS scores for statistical analysis. (n = 12 per group). * at the top of each group's statistical graph indicates the difference analysis with the NS group. Data presented the mean ± SD (n = 6 per group, except for data G) (*P < 0.05, **P < 0.01, ***P < 0.001 and ns not significant)