. 2021 May 17;60(9):604–615. doi: 10.1002/gcc.22956

TABLE 1.

Details of high hyperdiploid cases which clustered with low hypodiploid and near triploid cases or vice versa by unsupervised hierarchical clustering analysis of standardized whole chromosome log2 ratios

Patient ID	Age (years)	Abnormal karyotype	Subgroup by				Mutations	Outcome
Patient ID	Age (years)	Abnormal karyotype	Cytogenetics	SNP array analysis	SNP array clustering	Decision tree node	Mutations	Outcome
26 910	43	54~56,XY,+1,add (2)(q3)x2,+3,add (3)(q2),+5,+6,?del (6)(q?2),+10,+11,+14,+?16,+18,+2mar,inc[cp8]	High hyperdiploid	LOH‐LCN	HoTr	HoTr	TP53 p.P151S	Died in CR1 within 1 year
27 478	58	59,XX,+X,+1,+2,+4,+6,+10,+12,+18,+19,+21,+21,+22,+22[10]	High hyperdiploid	LOH‐LCN	HoTr	HoTr	TP53 p.R282W	Relapsed and died within 2 years
29 491	51	58~59,XY,+?X,+1,+2,+6,add (8)(q2)x2,+10,+11,+12,+12,+14,idic (15)(p1),+18,add (18)(p1),+19,+21,+21,+22,+mar,inc[cp10]	High hyperdiploid	LOH‐LCN	HoTr	HoTr	TP53 p.K305*	CR1 (4 months)
24 805	46	53,XX,+5,+6,+10,+11,+20,+21,i (21)(q10),+22[8]	High hyperdiploid	Inconclusive	HoTr	Non‐ploidy	Not done	Died in CR1 within 1 year
27 058	7	64~66,XX,+X,+add (1)(p?2),+3,+4,+5,+6,+8,+10,+11,+12,+14,+14,+17,+18,+19,+20,+21,+21,+22,+mar[cp9]	Near triploid	HET‐CNG	High hyperdiploid	High hyperdiploid	Not done	CR1 (2 years)
28 893	27	75~80,XY,+X,+Y,+Y,+Y,+1,+1,+2,+2,+3,+4,+5,+5,+6,+7,+8,+9,+10,+11,+12,+13,+14,+14,+15,+15,+16,+16,+17,+17,+18,+18,+19,+19,+20,+20,+21,+21,+22,+22[cp4]	Near triploid	Inconclusive	High hyperdiploid	HoTr	IGH‐CRLF2JAK2 p.T875NTP53 not mutated	CR1 (1 year)

Note: Three cases with cytogenetic classification of HeH showed widespread LOH‐LCN, consistent with HoTr. This was further confirmed by TP53 mutations in all three cases. One case with a near triploid karyotype showed HET‐CNG on SNP array, consistent with HeH.

Abbreviations: HeH, high hyperdiploid; HET‐CNG, heterozygosity with copy number gains; HoTr, hypodiploid/near triploid; LCN, lower copy number; LOH, loss of heterozygosity.