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. Author manuscript; available in PMC: 2022 Aug 1.
Published in final edited form as: Mol Microbiol. 2021 Jun 25;116(2):707–722. doi: 10.1111/mmi.14765

Figure 8. Model for YneA-induced cell division inhibition.

Figure 8.

In the presence of DNA damage, cleavage of LexA allows for expression of the SOS-induced cell division inhibitor YneA. YneA expression must reach a critical threshold to bypass the negative regulators DdcA, DdcP and CtpA to activate the checkpoint. YneA localizes to the membrane, mediated by the transmembrane domain (TM), where it interacts with the late divisome proteins FtsL, Pbp2b and Pbp1 as well as binds peptidoglycan interfering with cell wall remodeling at the septum. After the DNA is repaired and YneA expression is repressed by LexA, YneA is cleared by the proteases DdcP and CtpA allowing septal cell wall synthesis to commence and cell division to resume.