Table 4.
Analytical method, cohort, main metabolic alterations of the four reviewed breast cancer studies.
| First Author (year) | Method | Cohort | Main metabolic alterations | Reference |
|---|---|---|---|---|
| Porto-Figueira (2018)a | NTME-GC–MS | 30 cancer − 60 control | Dysregulation in phenylalanine pathway, butanoate metabolism, and xenobiotics metabolism by cytochrome P450 | [56] |
| Silva (2012) | SPME-GC–MS | 26 cancer − 21 control | Dysregulation in ketones and sulfur compounds metabolism | [83] |
| Silva (2019) | SPME-GC–MS | 31 cancer − 40 control | Dysregulation in pyruvate pathway and sulfur compounds metabolism | [84] |
| Taunk | SPME-GC–MS | 65 cancer − 70 control | Dysregulation in pyruvate pathway, sulfur, ketones and tyrosine metabolism, and fatty acid biosynthesis | [85] |