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. Author manuscript; available in PMC: 2021 Nov 18.
Published in final edited form as: Nat Med. 2021 Jul 9;27(9):1600–1606. doi: 10.1038/s41591-021-01443-1

Extended Data Fig. 8 ∣. PCCOs show robust SARS-CoV-2 infection compared to COs.

Extended Data Fig. 8 ∣

a-b, SNP and GFAP staining shows few SNP+ cells in COs (a) and robust SNP+ cells in PCCOs (b) 72 h after SARS-CoV-2 virus exposure. Bar: 400 μm. DAPI: blue, GFP: PLCs, GFAP: astrocytes, and SNP: SARS-CoV-2-NP. The dashed white boxes show the 20x region shown in Fig. 3b-e. Bar: 400 μm. In a-b, n = 9 includes three biological replicates (COs generated from H1, iPSC-Line2, iPSC-Line3) and three technical replicates (three COs for each of the biological replicates). Both COs and PCCOs shown were generated from H1 cells and GFP-PLCs were derived from H9 cells.

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