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. Author manuscript; available in PMC: 2021 Nov 18.
Published in final edited form as: Allergy. 2018 Nov 20;74(2):236–245. doi: 10.1111/all.13567

Figure 4. sFcεRI prevents systemic sensitization and improves recovery.

Figure 4.

Analysis of core body temperature from passively (A-C) and systemically (D, E) sensitized mice. Panel A shows the passive sensitization and challenge strategy. Panel B shows the time course of core body temperature drop in sensitized mice that were challenged in the absence or presence of rsFcεRI. Representative experiment, average temperature of 3–6 mice per time point. Panel C shows the composite graph of temperature drops at the 20 min time point following DNP-OVA challenge, from three independent experiments (n= 3, total of 19 mice). Panel D shows the Th2-type sensitization and challenge strategy. Panel E shows the time course of body temperature drop in sensitized mice that were challenged with OVA in absence or presence of rsFcεRI 24 hours before challenge. rsFcεRI (3 μg), IgE-anti-DNP (5 μg), OVA/Alum (100 μg), and OVA (100–500 μg). Graphs show mean ± SEM with n=3–6/group where 1way ANOVA test and Tukey’s multiple correction (C), or 2way ANOVA tests and Tukey’s (B) or Bonferroni’s (E) multiple correction were performed; *p<0.05; **p<0.01; ***p<0.001, and ****p<0.0001. * represents statistics between IgE and dIgE (B), and PBS and OVA (E) groups, *§ represents statistics between IgE-anti-DNP and IgE-anti-DNP + rsFcεRI (B), and OVA and OVA+24h rsFcεRI (E) groups.