. Author manuscript; available in PMC: 2021 Nov 18.

Published in final edited form as: Curr Opin Virol. 2017 May 21;24:97–104. doi: 10.1016/j.coviro.2017.04.006

Table 1.

Receptor binding gHgL entry complexes (EC) for Human Herpesvirus (HHV) that trigger entry

Herpesvirus	Glycoprotein complex	Entry receptor	Cell type infected
Herpes Simplex Virus (HSV-1 and HSV-2)	gHgL-gD	Herpesvirus entry mediator (HVEM), Nectin-1, 3-O-sulphated heparan sulphate	Neurons, Fibroblasts, Epithelial cells
Varicella Zoster virus (VZV)	gHgL	Integrins	Respiratory mucosa, T-cells, Neurons
Cytomegalovirus (CMV)	gHgL/UL128/UL130/UL131 (Pentamer)	ErbB?	Epithelial, Endothelial and Myeloid cells
Cytomegalovirus (CMV)	gHgL/gO (Trimer)	Platelet-derived growth factor receptor alpha (PDGFRα)	Fibroblasts, Epithelial, Endothelial and Myeloid cells
Human Herpesvirus 6 (HHV-6A and HHV-6B)	gHgL/gQ1/gQ2	CD46 (strain specific)	T-cells
Human Herpesvirus 6 (HHV-6A and HHV-6B)	gHgL/gO	?	?
Epstein-Barr virus (EBV)	gHgL/gp42	HLA-class II (bind gp42)	B cells
Epstein-Barr virus (EBV)	gHgL	αvβ3, αvβ6 integrins	Epithelial cells
Kaposi’s sarcoma-associated herpesvirus (KSHV)	gHgL	EphA2	Endothelial cells