TABLE 1.
Nonsynonymous SNVs detected in clinical specimens of SARS-CoV-2a
| Coding region and genomic position | Codon change | Amino acid change | No. (%) |
|---|---|---|---|
| ORF1ab | |||
| 490 | GAU →GAA | D75E | 6 (3.3) |
| 1059 | ACC→AUC | T265I | 136 (75.1) |
| 3177 | CCU→CUU | P971L | 6 (3.3) |
| 11916 | UCA→UUA | S3884L | 11 (6.1) |
| 14408 | CCU→CUU | P4715L | 158 (87.3) |
| 18736 | UUU→CUU | F6158L | 6 (3.3) |
| 19684 | GUA→UUA | V6474L | 5 (2.8) |
| S | |||
| 23403 | GAU→GGU | D614G | 159 (87.8) |
| ORF3a | |||
| 25563 | CAG→CAU | Q57H | 147 (81.2) |
| 26144 | GGU→GUU | G251V | 6 (3.3) |
| ORF7a | |||
| 27635 | UCA→UUA | S81L | 5 (2.8) |
| ORF8 | |||
| 28077 | GUG→CUG | V62L | 6 (3.3) |
| 28144 | UUA→UCA | L84S | 12 (6.6) |
a
The nonsynonymous mutations listed are those that were detected in at least 2 of the 181 clinical samples that were sequenced successfully. Specimen collection dates ranged from 29 February 2020 to 29 April 2020.