FIG 4.
The contributions of smoking-related mutagens to the phenotypes. The heatmap shows the correlation coefficient between the mutational signatures identified 160 NS and 299 S (x-axis) samples and smoking-related mutagen signatures (y-axis) described by Kucab et al.31 AFR, African; AMR, Admixed American; ASN, Asian; CPTAC, Clinical Proteomic Tumor Analysis Consortium; EUR, European; FDR, false discovery rate; NS, never-smoker; PAH, polycyclic aromatic hydrocarbon; S, smoker; TCGA, The Cancer Genome Atlas.