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. 2021 Nov 17;7(12):e794. doi: 10.1097/TXD.0000000000001246

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Copyright © 2021 The Author(s). Transplantation Direct. Published by Wolters Kluwer Health, Inc.

This is an open-access article distributed under the terms of the Creative Commons Attribution-Non Commercial-No Derivatives License 4.0 (CCBY-NC-ND), where it is permissible to download and share the work provided it is properly cited. The work cannot be changed in any way or used commercially without permission from the journal.

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FIGURE 4. — Correlation between the number of S protein–specific IFN-γ–producing SFUs per 10⁶ PBMCs assessed by the IFN-γ FluoroSpot assay and the serum neutralizing activity against the S protein determined with an hACE-2/spike antibody inhibition ELISA-based method: (A) after the first dose of the mRNA-1273 vaccine; (B) at 2 wk after the completion of the full vaccine series. The cutoff value for positivity in the IFN-γ FluoroSpot assay (>25 SFUs/10⁶ PBMCs) is denoted by the blue dotted line. hACE, human angiotensin-converting enzyme; IFN-γ, interferon-γ; PMBC, peripheral blood mononuclear cell; S, SARS-CoV-2 spike glycoprotein; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; SFU, spot-forming unit.