TABLE 1.
Demographics and clinical characteristics of the study population (n = 44)
| Variable | |
|---|---|
| Age, y, mean ± SD | 52.4 ± 11.5 |
| Male gender, N (%) | 27 (61.4) |
| Smoking habit, N (%) | 7 (15.9) |
| Comorbidities, N (%) | |
| Hypertension | 32 (72.7) |
| Dyslipidemia | 12 (27.3) |
| Diabetes mellitus | 11 (25.0) |
| Cardiovascular disease | 14 (31.8) |
| Obesity | 6 (13.6) |
| Chronic pulmonary disease | 4 (9.1) |
| Venous thromboembolic disease | 7 (15.9) |
| Ethnicity, N (%) | |
| Caucasian | 38 (86.4) |
| Latino | 3 (6.8) |
| Other | 3 (6.8) |
| Type of transplantation, N (%) | |
| Kidney | 28 (63.6) |
| Liver | 14 (31.8) |
| Simultaneous kidney-pancreas | 1 (2.3) |
| Simultaneous liver-kidney | 1 (2.3) |
| Previous solid organ transplantation, N (%) | 5 (11.4) |
| Time interval since transplantation, y, median (IQR) | 2.3 (1.3–4.8) |
| Type of immunosuppression regimen, N (%)a | |
| Tacrolimus, MMF/MPS and prednisone | 23 (52.3) |
| Tacrolimus and MMF/MPS | 5 (11.4) |
| Tacrolimus, MMF/MPS and mTOR inhibitor | 4 (9.1) |
| Tacrolimus monotherapy | 4 (9.1) |
| MMF/MPS and mTOR inhibitor | 2 (4.5) |
| Otherb | 6 (13.6) |
| Laboratory and immunological parameters, mean ± SDa | |
| eGFR, mL/min/1.73 m2 | 57.5 ± 21.8 |
| CD3+ T-cell count, cells/μL | 926 ± 481 |
| CD4+ T-cell count, cells/μL | 444 ± 273 |
| CD8+ T-cell count, cells/μL | 446 ± 313 |
| B-cell count, cells/μL | 112 ± 85 |
| NK cell count, cells/μL | 189 ± 154 |
| Serum IgG levels, mg/dL | 1140 ± 476 |
| Serum IgA levels, mg/dL | 276 ± 140 |
| Serum IgM levels, mg/dL | 121 ± 86 |
aAt the time of the administration of the first dose of the mRNA-1273 vaccine.
bCyclosporine, MMF and prednisone (n = 1); MPA, everolimus, and prednisone (n = 1); tacrolimus, azathioprine, and prednisone (n = 1); tacrolimus and prednisone (n = 1); everolimus and prednisone (n = 1); MMF monotherapy (n = 1).
eGFR, estimated glomerular filtration rate (estimated by the Modification of Diet in Renal Disease-4 equation); IgA, immunoglobulin A; IgG, immunoglobulin G; IgM, immunoglobulin M; IQR, interquartile range; MMF/MPS, mycophenolate mofetil or mycophenolate sodium; mTOR, mammalian target of rapamycin; NK, natural killer; SD, standard deviation.