Table 2.
Experimental group (N = 94) | Control group (N = 77) | P value | |
Primary outcomes | |||
ADL | |||
Before treatment | 34.36 ± 6.402 | 33.51 ± 5.853 | .368 |
On the days 14 | 53.72 ± 8.948 | 49.48 ± 7.805 | .001 |
On the months 3 | 67.45 ± 12.109 | 58.64 ± 9.306 | <.001 |
On the months 6 | 85.85 ± 10.540 | 80.13 ± 13.002 | .002 |
mRS | |||
Before treatment | 3.98 ± 0.145 | 3.96 ± 0.195 | .498 |
On the days 14 | 3.22 ± 0.571 | 3.40 ± 0.494 | .031 |
On the months 3 | 2.64 ± 0.526 | 3.06 ± 0.439 | <.001 |
On the months 6 | 1.57 ± 1.042 | 1.99 ± 0.803 | .005 |
Secondary outcomes | |||
NIHSS | |||
Before treatment | 17.07 ± 2.263 | 17.10 ± 2.326 | .934 |
On the days 14 | 11.90 ± 2.379 | 12.73 ± 2.315 | .024 |
On the month 1 | 6.59 ± 3.244 | 7.65 ± 3.417 | .039 |
HAMA | |||
On the months 3 | 15 (16.0%) | 26 (33.8%) | .007 |
On the months 6 | 17 (18.1%) | 29 (37.7%) | .005 |
HAMD | |||
On the months 3 | 9 (9.6%) | 19 (24.7%) | .012 |
On the months 6 | 14 (14.9%) | 25 (32.5%) | .010 |
Safety outcomes | |||
Primary intracranial hemorrhage | 0 | 0 | |
Gastrointestinal hemorrhage | 2 (2.1%) | 3 (3.9%) | .659 |
Nasal and gum bleeding | 5 (5.3%) | 4 (5.2%) | 1.000 |
Subcutaneous hemorrhage | 0 | 0 |
ADL = Barthel Index of activities of daily living, HAMA = Hamilton Anxiety Scale, HAMD = Hamilton Depression Scale, mRS = Modified Rankin Scale, NIHSS = National Institutes of Health Stroke Scale.