Table 2.

Pooled hazard ratios of patients’ survival according to subgroup analyses.

						Heterogeneity
Subgroup	No. of studies	No. of patients	HR (95%CI)	Model	P value	I2 (%)	P
Overall	6	771	2.393 (1.949, 2.938)	Fixed	.000	0.0	.636
Country
Japan	4	429	2.604 (1.968, 3.445)	Fixed	.000	0.0	.465
China	1	148	2.256 (1.531, 3.324)	–	.000	–	–
UK	1	194	2.040 (1.261, 3.301)	–	.004	–	–
Cutoff value of CAR
≥0.1	4	481	2.324 (1.816, 2.974)	Fixed	.000	0.0	.589
<0.1	2	290	2.555 (1.764, 3.699)	Fixed	.000	24.7	.249
Treatment
chemotherapy	3	287	2.435 (1.827, 3.245)	Fixed	.000	0.0	.464
surgery	1	194	2.040 (1.261, 3.301)	–	.004	–	–
mixed	2	290	2.555 (1.764, 3.699)	Fixed	.000	24.7	.249
Sample size
≥150	2	378	2.499 (1.754, 3.559)	Fixed	.000	32.5	.223
<150	4	393	2.341 (1.819, 3.012)	Fixed	.000	0.0	.604
NOS score
≥7	4	583	2.337 (1.814, 3.012)	Fixed	.000	0.0	.602
<7	2	188	2.502 (1.764, 3.549)	Fixed	.000	31.7	.226
Follow-up (mo)
≥60	3	353	2.214 (1.698, 2.887)	Fixed	.000	0.0	.945
<60	3	418	2.687 (1.943, 3.715)	Fixed	.000	19.6	.288

CAR = C-reactive protein to albumin ratio, CI = confidence interval, HR = hazard ratio, NOS = Newcastle–Ottawa Quality Assessment Scale.