Table 4.
Pooled results | Heterogeneity | |||||
Subgroups | No. of study/pts | MD | 95% CI | P-value | I 2 | Analytical effect model |
Year | ||||||
Before 2010 | 3/254 | −0.04 | −0.10 to 0.02 | . 17 | 63% | Random-effect model |
After 2010 | 3/601 | −0.04 | −0.07 to −0.00 | .03 | 19% | Fixed effect model |
Mean age | ||||||
<50 yr | 2/44 | −0.06 | −0.16 to 0.05 | .32 | 76% | Random-effect model |
≥50 yr | 4/811 | −0.03 | −0.05 to −0.01 | .02 | 0% | Fixed effect model |
Quality | ||||||
Moderate | 2/44 | −0.06 | −0.16 to 0.05 | .32 | 76% | Random-effect model |
High | 4/811 | −0.03 | −0.05 to −0.01 | .02 | 0% | Fixed effect model |
Instruments | ||||||
DXA | 5/363 | −0.04 | −0.06 to −0.01 | .001 | 40% | Fixed effect model |
DPA | 1/492 | 0.00 | −0.06 to 0.06 | 1.00 | – | – |
Ethnicity | ||||||
Caucasians | 4/153 | −0.06 | −0.09 to −0.02 | .0007 | 29% | Fixed effect model |
Asians | 2/702 | −0.02 | −0.04 to 0.01 | .27 | 0% | Fixed effect model |
Sample size | ||||||
≤100 pts | 4/153 | −0.06 | −0.09 to −0.02 | .0007 | 29% | Fixed effect model |
>100 pts | 2/702 | −0.02 | −0.04 to 0.01 | .27 | 0% | Fixed effect model |
Gender | ||||||
Female | 3/279 | −0.05 | −0.10 to −0.00 | .04 | 60% | Random-effect model |
Male/female | 3/576 | −0.02 | −0.06 to 0.01 | .19 | 25% | Fixed effect model |
CI = confidence intervals, MD = mean difference.