Table 1.

Characteristics of the included studies.

Author	Year	Country	Age	Sample (Case/control)	Specimen	Dysregulated status	Cutoff value	TP	FP	FN	TN	QUADAS-2
Abd-El-Fattah et al[19]	2013	Egypt	Adult	29/37	Serum	Up	Unclear	28	14	1	23	7
Cai et al[24]	2016	China	Child	30/30	Serum	Up	1.20	26	3	4	27	5
Cao et al[25]	2014	China	Child	40/60	Serum	Up	0.71	32	6	8	54	5
Chen et al[26]	2020	China	Adult	68/32	Sputum	Up	Unclear	64	2	4	30	6
Chen et al[27]	2017	China	Adult	100/45	Serum	Down	0.36	81	13	19	32	5
Kathirvel et al[16]	2020	India	Child	30/30	Serum	Up	0.70	28	1	2	29	7
Ndzi et al[20]	2019	Cameroon	Adult	83/42	Serum	Up	Unclear	66	21	17	21	6
Shi et al[28]	2019	China	Adult	72/45	Serum	Down	Unclear	30	7	42	38	7
Wagh et al[21]	2017	India	Adult	30/30	Serum	Down	Unclear	29	3	1	27	6
Wu et al[22]	2012	China	Adult	21/19	Serum	Up	Unclear	10	1	11	18	7
Zhou et al[23]	2016	China	Child	68/32	Serum	Up	Unclear	24	3	1	18	7
Ying et al[29]	2020	China	Adult	68/122	Sputum	Up	Unclear	64	15	4	107	7

FN = false-negative, FP = false-positive, QUADAS-2 = quality assessment of diagnostic accuracy studies-2, TN = true-negative, TP = true-positive.