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. 2021 Nov 4;12:756978. doi: 10.3389/fphar.2021.756978

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Copyright © 2021 Wang, Zhang, Xu, Ma, Lu, Ma, Liu, Wang and Tang.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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MGQD attenuated DSS-induced colonic inflammation in a gut microbiota dependent manner. (A) Experimental timeline. (B) Total DNA concentration from the gut microbiota in mice fecal samples. (C) Body weight change. (D) DAI score. (E) Representative photograph of colons. (F) Statistics of colon length. (G) The histological scores of mouse colon morphology. (H) Histological changes of the colon based on HE staining (magnification,×200). Data were expressed as mean ± SD (n = 10). #p < 0.05, ###p < 0.001 vs ABX group, NS means no statistical significance. ABX: a gut microbiota depletion group; ABX (DSS): an antibiotic-disposed UC model group; ABX (DSS + GH): an antibiotic-disposed UC model treatment group.