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. 2021 Nov 18;16(11):e0260254. doi: 10.1371/journal.pone.0260254

Fig 4. Relationship between serum levels of cytokines (IL–6 or TNF–α) and sTIM–3 in the sub–grouped RA patients according to the titers of ACPA.

Fig 4

There were significant correlations between serum levels of cytokines (IL–6 or TNF–α) and sTIM–3 in RA patients with low-medium levels of ACPA titers (<200 U/mL). However, there was no significant correlation between serum levels of cytokines (IL–6 or TNF–α) and sTIM–3 in RA patients with high titers of ACPA (≥200 IU/mL). The correlations were determined using Spearman’s rank correlation test.