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. 2021 Nov 8;17(11):e1009880. doi: 10.1371/journal.pgen.1009880

Fig 5. Mutations affecting the FLP-14/FRPR-19 pathway cause fast habituation of responses to noxious heat and harsh touch.

Fig 5

(A, B, C) Impact of frpr-19 mutation on noxious heat-evoked reversals. Reversal length comparison, based on a five-trial assay (A) or across a longer habituation protocol of ten repeated stimuli (C). Normalized reversal response, expressed as fraction of the maximal response rate and showing faster habituation in frpr-19 mutant (B). (D-I). Impact of frpr-19 and flp-14 mutations on harsh touch-evoked reversals. Reversal length comparison, based on a five-trial assay (D, G) or across a longer habituation protocol of ten repeated stimuli (F, I). Normalized reversal response, expressed as fraction of the maximal response rate and showing faster habituation in frpr-19 mutant (E, H). (J) Impact of frpr-19 and flp-14 mutations on optogenetic FLP stimulation-evoked reversals in a ten-stimuli habituation protocol, showing a faster habituation in the mutants. *, p < .01 versus corresponding wild type data point by Bonferroni contrasts (B, E, H, J). The data without normalization corresponding to panels B, E, H and J are presented in S3 Fig.