. Author manuscript; available in PMC: 2021 Nov 18.

Published in final edited form as: J Cancer Ther. 2021 Sep 29;12(9):505–529. doi: 10.4236/jct.2021.129044

Table 3.

A summary of P-values associated with DVH indices for a family of Cox models that represent heart dosimetry as a single, whole heart DVH. Index V_D indicates percentage of heart volume receiving a dose greater or equal to D[Gy]. P-values are lowest in the same range of V_D as non-zero indices of the KC-Lasso model. Since the lowest p-value is associated with V55, which is also located in the middle of the KC-Lasso range, we choose V55 as the best approximation which can be used in treatment planning. The Hazard Ratio associated with V55 is HR = 1.044 for each 1% of the heart volume exposed to at least 55 Gy.

DVH index	V5	V10	V15	V20	V25	V30
P-value	0.55	0.53	0.46	0.37	0.31	0.42
DVH index	V35	V40	V45	V50	V55	V60
P-value	1.00	0.65	0.33	0.09	0.03	0.08