Figure 6. T-cell deficits are found in the blood of Atm^R35X/R35X; Aptx^−/− mice.

(A) Representative flow cytometric profiles of T-cell glycoprotein marker CD3 and summary plots indicate ATM- and/or APTX-deficient mice have decreased proportions of CD3⁺ T-cells in the blood. (B) Representative flow cytometric profiles of T-cell glycoprotein markers CD4 and CD8 gated on CD3⁺ cells and summary plots for CD8 and CD4 single positive cell proportions. ATM-deficient mice had reduced CD4⁺ proportions compared to mice with at least one copy of the Atm gene. Statistical significances were assessed via one-way ANOVA followed by Tukey’s pairwise multiple comparisons test. Number of animals denoted at bottom of bar. Symbol/color key: Atm^+/+; Aptx^+/+ (purple circle), Atm^R35X/R35X; Aptx^+/+ (green triangle), Atm^R35X/+; Aptx^−/− (red inverted triangle), Atm^R35X/R35X; Aptx^−/− (orange square). ATM, Ataxia Telangiectasia mutated.