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. 2021 Sep 29;10:e66609. doi: 10.7554/eLife.66609

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© 2021, Kim et al

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Figure 4. — (a) Schematic of photometry experiment from SON-projecting SFO^Vglut2 and MnPO/OVLT^Vglut2 neurons. (b) Single-trial timecourses of SON-projecting SFO^Vglut2 (top) and MnPO/OVLT^Vglut2 (bottom) population activity in response to water bowl placement. Trials are sorted according to latency from water bowl placement to drinking onset (black ticks). n=7 (SFO^Vglut2), and 5 (MnPO/OVLT^Vglut2) mice. (c) Average population activity of SON-projecting SFO^Vglut2 (light blue) and MnPO/OVLT^Vglut2 (dark blue) neurons in response to water bowl placement. n=7 (SFO^Vglut2), and 5 (MnPO/OVLT^Vglut2) mice. (d) Average pre-ingestive responses of SON-projecting SFO^Vglut2 (light blue) and MnPO/OVLT^Vglut2 (dark blue) neurons. n=7 (SFO^Vglut2), and 5 (MnPO/OVLT^Vglut2) mice. Values are means ± SEMs across trials. (e) Data from panel (c) binned across drinking periods. n=7 (SFO^Vglut2), and 5 (MnPO/OVLT^Vglut2) mice. (f) Normalized average SON-projecting SFO^Vglut2 and MnPO/OVLT^Vglut2 population activity binned across drinking periods. Values are normalized to the total change. ***p<0.001; two-way ANOVA, p<0.001, n=7 (SFO^Vglut2), and 5 (MnPO/OVLT^Vglut2) mice. (g) Schematic of photometry experiment from SON-projecting MnPO/OVLT^Vgat neurons. (h) Single-trial timecourses of SON-projecting MnPO/OVLT^Vgat population activity in response to water bowl placement. Trials are sorted according to latency from water bowl placement to drinking onset (black ticks). n=9 mice. (i) Average population activity of SON-projecting MnPO/OVLT^Vgat neurons in response to water bowl placement. n=9 mice. (j) Average pre-ingestive responses of SON-projecting MnPO/OVLT^Vgat neurons. n=9 mice. Values are means ± SEMs across trials. (k) Data from panel (i) binned across drinking periods. n=9 mice. Scale bar, 200 µm. Values are means ± SEMs across mice except for (d, j). MnPO, median preoptic nucleus; OVLT, organum vasculosum lamina terminalis; SFO, subfornical organ; SON, supraoptic nuclei.