Figure 2.

Cardiac energetics across the spectrum of diastolic dysfunction. A, Phosphorus magnetic resonance spectroscopy acquisition strategy with a voxel placed in the midventricular septum (red) and saturation bands (yellow) placed over skeletal muscle and the liver. B, Representative cardiac ³¹P spectra for the different study groups showing (C) progressive depletion of phosphocreatine (PCr)/ATP and associations with (D) NT-proBNP (N-terminal pro-brain natriuretic peptide) and (E) left ventricular (LV) E/e′ ratio. P values (ordered medians) reported are the result of Jonckheere-Terpstra test across the groups or from linear regression analysis. DPG indicates diphosphoglycerate; and T2D, type 2 diabetes.