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. 2021 Nov 8;144(21):1664–1678. doi: 10.1161/CIRCULATIONAHA.121.054858

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© 2021 The Authors.

Circulation is published on behalf of the American Heart Association, Inc., by Wolters Kluwer Health, Inc. This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution, and reproduction in any medium, provided that the original work is properly cited.

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Figure 4. — Cardiac energetics and diastolic filling at rest and during exercise. A, Representative examples of volume–time curves for the study groups. Second row: (B) peak left ventricular (LV) diastolic filling rates at rest, (C) peak LV diastolic filling rates during exercise, and (D) the stress-inducible change in peak LV diastolic filling rates across the groups. Third row: relationship between cardiac energetics at rest and (E) peak LV diastolic filling rates at rest, (F) peak LV diastolic filling rates during exercise, and (G) the stress-inducible change in peak LV diastolic filling rates across the groups. P values (ordered medians) reported are the result of Jonckheere-Terpstra test across the groups or from linear regression analysis. EDV/s indicates end-diastolic volume (in milliliters) per second; HFpEF, heart failure with preserved ejection fraction; PCr, phosphocreatine; and T2D, type 2 diabetes.