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Replication timing of wild-type and Δ2-5 loci in DT40 hybrids. Replication timing assays were performed as in MEL and GM979 hybrids. In DT40, both the wild-type and Δ2-5 human β-globin loci (HBG1+2 and 5′δ1+3) are late replicating relative to the early-replicating Fra11B control.
