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. Author manuscript; available in PMC: 2022 Mar 19.
Published in final edited form as: Basic Res Cardiol. 2021 Mar 19;116(1):19. doi: 10.1007/s00395-021-00858-8

Fig. 7.

Fig. 7

EV-derived-miR-106a–363 cluster activates cell cycle re-entry and proliferation in the injured myocardium until week-4 post-MI. a mRNA expression of cell cycle (G1/S, and G2/M) positive regulators and negative regulators (CDKIs) were analyzed in vivo. qRT-PCR analysis of in vivo mouse heart tissue was performed. Samples collected and analyzed at day 4 post-MI. Statistical significance was determined by one-way ANOVA with multiple comparisons and mean ± SD (n = 3). b qRT-PCR analysis of cell cycle marker in mouse heart tissues at week 4 (day 28) post-MI: (1) WT Ctrl: non-MI normal control; (2) MI Ctrl; (3) MI + Ctrl-miR; and (4) MI + Core-miRs. The expression levels were normalized to Gapdh. Statistical significance was determined by one-way ANOVA with multiple comparisons and mean ± SD (n = 4). Statistically non-significant comparisons are not shown. *p < 0.05, **p < 0.01, ***p < 0.001