(a).

Gene	Healthy versus periodontitis		Healthy versus T2DM+P		Periodontitis versus T2DM+P
SNP
LDLR	Adj OR (95% CI)	p value	Adj OR (95% CI)	p value	Adj OR (95% CI)	p value
rs5925
All patients†	Adjusted OR†		Adjusted OR†		Adjusted OR†
TT	Ref		Ref		Ref
CT	0.96 (0.68–1.36)	0.81	1.01 (0.62–1.62)	0.97	1.13 (0.73–1.75)	0.58
CC	0.92 (0.58–1.46)	0.72	1.12 (0.60–2.06)	0.71	1.02 (0.58–1.79)	0.93
X 2
Genotype	0.096		0.355		0.183
Allele	0.031		0.003		0.041
Male‡	Adjusted OR‡		Adjusted OR‡		Adjusted OR‡
TT	Ref		Ref		Ref
CT	1.31 (0.73–2.37)	0.36	1.21 (0.50–2.89)	0.67	1.15 (0.56–2.36)	0.70
CC	1.13 (0.51–2.50)	0.76	2.50 (0.80–7.82)	0.11	1.07 (0.45–2.60)	0.86
Female‡
TT	Ref		Ref		Ref
CT	0.82 (0.53–1.27)	0.38	0.95 (0.53–1.69)	0.85	1.21 (0.64–1.94)	0.68
CC	0.83 (0.47–1.47)	0.52	0.81 (0.38–1.72)	0.59	0.99 (0.44–2.05)	0.97
Never smoking¶	Adjusted OR¶		Adjusted OR¶		Adjusted OR¶
TT	Ref		Ref		Ref
CT	0.91 (0.61–1.38)	0.68	1.04 (0.59–1.86)	0.87	1.16 (0.66–2.01)	0.59
CC	0.97 (0.57–1.70)	0.96	1.20 (0.57–2.50)	0.61	1.11 (0.55–2.23)	0.31
Ever smoking¶
TT	Ref		Ref		Ref
CT	1.07 (0.55–2.09)	0.83	0.86 (0.36–2.08)	0.73	1.01 (0.48–2.11)	0.97
CC	0.79 (0.32–1.89)	0.59	0.93 (0.30–2.87)	0.91	0.86 (0.33–2.22)	0.18
rs688
All patients†	Adjusted OR†		Adjusted OR†		Adjusted OR†
CC	Ref		Ref		Ref
CT	0.91 (0.65–1.29)	0.60	0.83 (0.52–1.35)	0.47	0.96 (0.62–1.49)	0.87
TT	0.88 (0.55–1.42)	0.61	0.97 (0.52–1.82)	0.93	0.90 (0.50–1.62)	0.74
X 2
Genotype	0.141		0.662		0.280
Allele	0.070		0.116		0.014
Male‡	Adjusted OR‡		Adjusted OR‡		Adjusted OR‡
CC	Ref		Ref		Ref
CT	1.30 (0.73–2.33)	0.37	1.15 (0.49–2.65)	0.75	0.99 (0.50–1.98)	0.99
TT	0.99 (0.45–2.21)	0.99	1.47 (0.47–4.56)	0.50	0.81 (0.32–2.05)	0.67
Female‡
CC	Ref		Ref		Ref
CT	0.76 (0.49–1.16)	0.48	0.73 (0.40–1.32)	0.32	0.94 (0.54–1.65)	0.84
TT	0.83 (0.46–1.50)	0.55	0.83 (0.39–1.80)	0.65	0.98 (0.46–2.08)	0.96
Never smoking¶	Adjusted OR¶		Adjusted OR¶		Adjusted OR¶
CC	Ref		Ref		Ref
CT	0.90 (0.60–1.36)	0.63	0.84 (0.47–1.50)	0.55	0.91 (0.52–1.58)	0.73
TT	0.95 (0.54–1.65)	0.54	1.06 (0.50–2.32)	0.87	0.99 (0.46–2.04)	0.99
Ever smoking¶
CC	Ref		Ref		Ref
CT	0.92 (0.48–1.77)	0.80	0.76 (0.32–1.81)	0.53	0.95 (0.46–1.97)	0.90
TT	0.73 (0.29–1.81)	0.50	0.78 (0.24–2.51)	0.67	0.73 (0.27–1.99)	0.54