(c).
| ABCC8 | Adj OR (95% CI) | p value | Adj OR (95% CI) | p value | Adj OR (95% CI) | p value |
|---|---|---|---|---|---|---|
| rs6544718 | ||||||
| All patients† | Adjusted OR† | Adjusted OR† | Adjusted OR† | |||
| CC | Ref | Ref | Ref | |||
| CT | 0.87 (0.60–1.25) | 0.45 | 0.71 (0.45–1.12) | 0.15 | 0.93 (0.57–1.52) | 0.79 |
| TT | 1.21 (0.43–3.39) | 0.71 | 0.64 (0.15–2.70) | 0.54 | 0.42 (0.10–1.73) | 0.23 |
| X 2 | ||||||
| Genotype | 1.023 | NA | NA | |||
| Allele | 0.072 | 0.901 | 1.377 | |||
| Male‡ | Adjusted OR‡ | Adjusted OR‡ | Adjusted OR‡ | |||
| CC | Ref | Ref | Ref | |||
| CT | 0.75 (0.41–1.37) | 0.35 | 0.37 (0.16–0.83) | 0.01 | 0.74 (0.29–1.87) | 0.52 |
| TT | 0.75 (0.10–5.45) | 0.77 | 0.89 (0.12–6.19) | 0.90 | 1.96 (0.16–22.84) | 0.59 |
| Female‡ | ||||||
| CC | Ref | Ref | Ref | |||
| CT | 0.95 (0.60–1.50) | 0.84 | 1.01 (0.57–1.77) | 0.96 | 1.06 (0.60–1.89) | 0.82 |
| TT | 1.43 (0.42–4.76) | 0.55 | 0.40 (0.04–3.99) | 0.44 | 0.17 (0.02–1.55) | 0.11 |
| Never smoking¶ | Adjusted OR¶ | Adjusted OR¶ | Adjusted OR¶ | |||
| CC | Ref | Ref | Ref | |||
| CT | 0.90 (0.59–1.38) | 0.65 | 0.69 (0.38–1.27) | 0.24 | 0.66 (0.36–1.20) | 0.17 |
| TT | 0.59 (0.14–2.39) | 0.46 | 1.36 (0.08–22.70) | 0.83 | 0.15 (0.01–1.35) | 0.09 |
| Ever smoking†¶ | ||||||
| CC | Ref | Ref | Ref | |||
| CT | 0.78 (0.39–1.54) | 0.47 | 0.72 (0.36–1.44) | 0.35 | 1.88 (0.71–4.98) | 0.20 |
| TT | 3.94 (0.46–33.82) | 0.21 | 0.51 (0.89–2.91) | 0.45 | 2.46 (0.29–20.84) | 0.40 |
| rs6544713 | ||||||
| All patients† | Adjusted OR† | Adjusted OR† | Adjusted OR† | |||
| CC | Ref | Ref | Ref | |||
| CT | 1.06 (0.76–1.49) | 0.69 | 0.93 (0.61–1.41) | 0.74 | 1.04 (0.66–1.62) | 0.86 |
| TT | 1.10 (0.61–1.98) | 0.74 | 1.30 (0.63–2.67) | 0.46 | 1.21 (0.59–2.4) | 0.59 |
| X 2 | ||||||
| Genotype | 0.379 | 0.491 | 0.081 | |||
| Allele | 0.384 | 0.504 | 0.032 | |||
| Male‡ | Adjusted OR‡ | Adjusted OR‡ | Adjusted OR‡ | |||
| CC | Ref | Ref | Ref | |||
| CT | 1.04 (0.59–1.81) | 0.84 | 0.75 (0.39–1.45) | 0.40 | 0.73 (0.34–1.56) | 0.42 |
| TT | 0.67 (0.22–2.03) | 0.48 | 0.61 (0.16–2.30) | 0.47 | 1.32 (0.29–6.06) | 0.71 |
| Female‡ | ||||||
| CC | Ref | Ref | Ref | |||
| CT | 1.06 (0.69–1.62) | 0.78 | 1.07 (0.62–1.83) | 0.80 | 1.25 (0.71–2.18) | 0.42 |
| TT | 1.34 (0.66–2.71) | 0.40 | 1.90 (0.79–4.57) | 0.15 | 1.23 (0.55–2.74) | 0.59 |
| Never smoking¶ | Adjusted OR¶ | Adjusted OR¶ | Adjusted OR¶ | |||
| CC | Ref | Ref | Ref | |||
| CT | 0.89 (0.60–1.33) | 0.58 | 0.88 (0.51–1.50) | 0.64 | 0.84 (0.49–1.44) | 0.54 |
| TT | 1.02 (0.51–2.02) | 0.94 | 1.46 (0.57–3.71) | 0.41 | 0.86 (0.36–2.04) | 0.73 |
| Ever smoking†¶ | ||||||
| CC | Ref | Ref | Ref | |||
| CT | 1.70 (0.88–3.26) | 0.10 | 1.00 (0.51–1.94) | 0.99 | 1.52 (0.66–3.53) | 0.32 |
| TT | 1.29 (0.39–4.20) | 0.67 | 1.06 (0.34–3.27) | 0.91 | 2.84 (0.73–10.95) | 0.12 |