(f).

APOE	Adj OR (95% CI)	p value	Adj OR (95% CI)	p value	Adj OR (95% CI)	p value
rs429358
All patients†	Adjusted OR†		Adjusted OR†		Adjusted OR†
TT	Ref		Ref		Ref
CT	1.06 (0.73–1.54)	0.73	0.84 (0.52–1.36)	0.48	0.84 (0.45–1.12)	0.15
CC	1.79 (0.63–5.05)	0.27	0.43 (0.11–1.64)	0.21	0.64 (0.15–2.7)	0.54
X 2
Genotype	1.032		NA		NA
Allele	0.611		0.399		1.649
Male‡	Adjusted OR‡		Adjusted OR‡		Adjusted OR‡
TT	Ref		Ref		Ref
CT	1.22 (0.64–2.33)	0.54	0.73 (0.34–1.53)	0.41	0.86 (0.36–2.05)	0.73
CC	4.76 (0.56–40.48)	0.15	1	—	1	—
Female‡
TT	Ref		Ref		Ref
CT	0.98 (0.62–1.56)	0.96	0.91 (0.48–1.72)	0.79	0.69 (0.36–1.31)	0.26
CC	1.06 (0.28–3.95)	0.92	0.78 (0.18–3.36)	0.74	2.28 (0.31–16.53)	0.41
Never smoking¶	Adjusted OR¶		Adjusted OR¶		Adjusted OR¶
TT	Ref		Ref		Ref
CT	1.15 (0.74–1.79)	0.52	0.86 (0.47–1.60)	0.65	0.87 (0.47–1.61)	0.67
CC	0.93 (0.28–5.36)	0.77	0.60 (0.11–3.31)	0.56	5.04 (0.39–63.54)	0.21
Ever smoking†¶
TT	Ref		Ref		Ref
CT	0.88 (0.43–1.77)	0.72	0.76 (0.34–1.66)	0.49	0.40 (0.14–1.09)	0.07
TT	1	—	1	—	8.56 (0.42–174.7)	0.16
rs7412
All patients
CC	Ref		Ref
CT	0.91 (0.55–1.50)	0.72	1.15 (0.63–2.08)	0.64	1.30 (0.69–2.46)	0.41
TT	1	—	1	—	3.41 (0.50–23.19)	0.20
X 2
Genotype	NA		NA		NA
Allele	1.831		0.4281		3.407
Male‡	Adjusted OR‡		Adjusted OR‡		Adjusted OR‡
CC	Ref		Ref		Ref
CT	1.13 (0.45–2.82)	0.78	1.87 (0.71–4.92	0.20	2.92 (0.88–9.63)	0.07
TT	1	—	1	—	1.29 (0.01–142.0)	0.91
Female‡
CC	Ref		Ref		Ref
CT	0.83 (0.45–1.52)	0.56	0.84 (0.39–1.84)	0.68	0.92 (0.41–2.03)	0.83
TT	1	—	1	—	4.03 (0.46–34.93)	0.20
Never smoking¶	Adjusted OR¶		Adjusted OR¶		Adjusted OR¶
CC	Ref		Ref		Ref
CT	0.97 (0.53–1.76)	0.93	1.40 (0.69–2.83)	0.34	1.64 (0.79–3.40)	0.17
TT	1	—	1	—	2.35 (0.16–33.59)	0.52
Ever smoking†¶
CC	Ref		Ref		Ref
CT	0.77 (0.30–1.95)	0.58	0.71 (0.23–2.17)	0.55	0.83 (.020–3.33)	0.79
TT	1	—	1	—	8.56 (0.42–174.7)	0.16