Table 4.
Regression coefficients and 95% CI for effects of SNPs on periodontal parameters (performed by multiple linear regression analysis).
| SNP | Number of remaining teeth | Marginal bleeding (% of sites) | BOPi (% of sites) | PPDi ≥ 5 mm (% of sites) | CALi ≥ 6 mm (% of sites) | |||||
|---|---|---|---|---|---|---|---|---|---|---|
| Adjusted β† (95% CI) | p value | Adjusted β† (95% CI) | p value | Adjusted β† (95% CI) | p value | Adjusted β† (95% CI) | p value | Adjusted β† (95% CI) | p value | |
| LDLR | ||||||||||
| rs5925 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.01 (-0.83–0.06) | 0.79 | 0.01 (-0.06–0.08) | 0.71 | -0.38 (-2.10–1.34) | 0.67 | 0.04 (-1.78–1.87) | 0.96 | -0.38 (-2.10–1.34) | 0.67 |
| CC | -0.15 (-0.30–<0.01) | 0.05 | -0.17 (-0.33–0.24) | 0.02 | -1.25 (-4.82–2.33) | 0.49 | 0.01 (-3.78–3.80) | 1.00 | -1.25 (-4.82–2.33) | 0.49 |
| rs688 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.01 (-0.08–0.04) | 0.62 | -<0.01 (-0.06–0.06) | 0.92 | 0.01 (-0.03–0.06) | 0.56 | <0.01 (-0.06–0.06) | 0.97 | -0.01 (-0.07–0.05) | 0.74 |
| TT | -0.02 (-0.11–0.06) | 0.60 | <0.01 (-0.08–0.09) | 0.86 | 0.01(-0.05–0.08) | 0.59 | <0.01 (-0.08–0.08) | 0.96 | -0.02 (-0.11–0.05) | 0.50 |
| APOB | ||||||||||
| rs676210 | ||||||||||
| GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AG | 0.04 (-0.01–0.11) | 0.14 | 0.05 (-<0.01–0.12) | 0.08 | 0.05 (<0.01–0.10) | 0.02 | 0.05 (-<0.01–0.12) | 0.06 | 0.07 (0.01–0.14) | 0.01 |
| AA | 0.01 (-0.11–0.14) | 0.82 | 0.08 (-0.04–0.21) | 0.21 | 0.06 (-0.03–0.17) | 0.18 | 0.07 (-0.05–0.20) | 0.24 | 0.07 (-0.05–0.19) | 0.27 |
| rs1042031 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.08 (-0.14–0.01) | 0.017 | -.05 (-0.11–0.01) | 0.13 | -0.05 (-0.10–<0.01) | 0.03 | -0.08 (-0.14–0.02) | 0.008 | -0.07 (-0.13–0.01) | 0.01 |
| TT | -0.03 (-0.21–0.15) | 0.73 | -0.08 (-0.26–0.09) | 0.36 | -0.13 (-0.28–<0.01) | 0.05 | -0.11 (-0.28–0.06) | 0.20 | -0.10 (-.27–0.07) | 0.24 |
| rs693 | ||||||||||
| GG | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AG | <0.01 (-0.06–0.06) | 0.93 | <0.01 (-0.05–0.07) | 0.87 | -<0.01 (-0.05–0.04) | 0.99 | <0.01 (-0.05–0.07) | 0.76 | 0.01 (-0.05–0.07) | 0.74 |
| AA | -<0.01 (-0.09–0.08) | 0.96 | -0.02 (-0.11–0.06) | 0.52 | -0.04 (-0.10–0.02) | 0.23 | -0.03 (-0.11–0.05) | 0.43 | -0.06 (-0.15–0.02) | 0.13 |
| ABCC8 | ||||||||||
| rs6544718 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.02 (-0.09–0.04) | 0.45 | -0.03 (-0.10–0.03) | 0.31 | 0.01 (-0.03–0.06) | 0.61 | 0.01 (-0.05–0.07) | 0.69 | 0.01 (-0.05–0.07) | 0.76 |
| TT | 0.10 (-0.09–0.30) | 0.29 | 0.05 (-0.14–0.24) | 0.58 | 0.09 (-0.05–0.24) | 0.19 | 0.06 (-0.12–0.24) | 0.52 | 0.05 (-0.12–0.24) | 0.53 |
| rs6544713 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | 0.05 (-0.01–0.11) | 0.10 | <0.01 (-0.06–0.06) | 0.99 | <0.01 (-0.04–0.05) | 0.74 | -<0.01 (-0.06–0.05) | 0.83 | -<0.01 (-0.06–0.05) | 0.77 |
| TT | 0.07 (-0.03–0.18) | 0.19 | 0.03 (-0.07–0.14) | 0.56 | -<0.01 (-0.09–0.07) | 0.82 | -0.01 (-0.11–0.09) | 0.81 | -0.01 (-0.11–0.09) | 0.81 |
| LPL | ||||||||||
| rs285 | ||||||||||
| TT | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.02 (-0.09–0.04) | 0.50 | -0.02 (-0.09–0.04) | 0.49 | -<0.01 (-0.06–0.04) | 0.79 | -0.05 (-0.11–0.01) | 0.11 | -0.04 (-0.10–0.02) | 0.22 |
| CC | -0.03 (-0.11–0.05) | 0.46 | -0.02 (-0.10–0.05) | 0.58 | <0.01 (-0.06–0.06) | 1.00 | -0.01 (-0.08–0.06) | 0.75 | -0.01 (-0.09–0.06) | 0.71 |
| rs3735964 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AC | -0.03 (-0.11–0.04) | 0.41 | -0.01 (-0.08–0.06) | 0.77 | -0.04 (-0.10–0.01) | 0.15 | -0.04(-0.11–0.03) | 0.26 | -0.03 (-0.10–0.04) | 0.42 |
| AA | -0.11 (-0.39–0.15) | 0.39 | -0.08 (-0.35–0.18) | 0.54 | -0.08 (-0.29–0.11) | 0.40 | -0.07 (-0.32–0.18) | 0.57 | -0.07 (-0.33–0.17) | 0.54 |
| rs13702 | ||||||||||
| TT | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.06 (-0.12–<0.01) | 0.06 | 0.02 (-0.09–0.03) | 0.40 | -0.01 (-0.06–0.03) | 0.62 | -0.02 (-0.08–0.04) | 0.51 | -0.03 (-0.09–0.02) | 0.29 |
| CC | -0.02 (-0.12–0.07) | 0.62 | -0.03 (-0.13–0.06) | 0.49 | 0.02 (-0.10–0.05) | 0.53 | -0.01 (-0.11–0.08) | 0.75 | -0.03 (-0.13–0.05) | 0.44 |
| HNF1A | ||||||||||
| rs2650000 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| AC | -0.02 (-0.09–0.03) | 0.36 | -0.04 (-0.11–0.01) | 0.13 | -0.04 (-0.09–<0.01) | 0.06 | -0.05 (-0.11–<0.01) | 0.09 | -0.04 (-0.10–0.01) | 0.13 |
| AA | 0.02 (-0.08–0.12) | 0.69 | <0.01 (-0.10–0.10) | 0.97 | <0.01 (-0.07–0.08) | 0.93 | -0.01 (-0.10–0.08) | 0.82 | 0.01 (-0.08–0.11) | 0.76 |
| APOE | ||||||||||
| rs429358 | ||||||||||
| TT | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -<0.01 (-0.07–0.06) | 0.89 | -<0.01 (-0.07–0.06) | 0.89 | 0.01 (-0.03–0.07) | 0.55 | -<0.01 (-0.06–0.06) | 0.96 | <0.01 (-0.06–0.07) | 0.91 |
| CC | 0.07 (-0.11–0.27) | 0.42 | 0.03 (-0.15–0.23) | 0.69 | 0.02 (-0.11–0.17) | 0.71 | 0.10 (-0.07–0.28) | 0.26 | 0.15 (-0.03–0.33) | 0.10 |
| rs7412 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | -0.03 (-0.13–0.05) | 0.41 | <0.01 (-0.08–0.10) | 0.85 | 0.02 (-0.04–0.09) | 0.45 | 0.03 (-0.05–0.11) | 0.49 | 0.02 (-0.06–0.11) | 0.63 |
| TT | -0.20 (-0.57–0.16) | 0.27 | -0.25 (-0.61–0.11) | 0.17 | -0.08 (-0.36–0.19) | 0.56 | -0.03 (-0.37–0.30) | 0.84 | -0.11 (-0.46–0.23) | 0.51 |
| HNF4A | ||||||||||
| rs1800961 | ||||||||||
| CC | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | |||||
| CT | 0.04 (-0.07–0.16) | 0.46 | 0.04 (-0.07–0.16) | 0.48 | -0.01 (-0.10–0.08) | 0.80 | -<0.01 (-0.1–0.11) | 0.94 | 0.02 (-0.08–0.14) | 0.64 |
| TT | -0.62 (-1.51–0.27) | 0.17 | -0.51 (-1.39–0.36) | 0.25 | -0.38 (-1.06–0.29) | 0.26 | -0.46 (-1.30–0.36) | 0.27 | 0.47 (-1.32–0.36) | 0.26 |
Bold font indicates p < 0.05. ∗Indicates statistical significance after Bonferroni's correction (p < 0.003). †The regression coefficients with 95% CI were estimated by multiple linear regression models after controlling for age, sex, and smoking. Abbreviations: PD: periodontal disease; β: regression coefficient; CI: confidence interval; PPDi: interproximal probing pocket depth; CALi: interproximal clinical attachment level.