Table 7. SoE grading: garlic intake by outcome1) .
Outcome | No. of studies [Reference] | SoE grade | Explanation | |
---|---|---|---|---|
RCTs | Observational studies | |||
Colorectal cancer | 1 [24] | 3 [29,30,31] | Inadequate | Only 1 RCT was rated as having a moderate RoB; Three cohort studies that were rated as having a moderate RoB presented inconsistent findings. |
Colon cancer | n/a | 4 [25,26,27,28] | Inadequate | No RCT; Three cohort studies and one case-cohort studies that were rated as having a moderate RoB presented inconsistent findings. |
Rectal cancer | n/a | 1 [27] | Inadequate | No RCT; Only 1 case-cohort study was rated as having a moderate RoB |
Proximal colon cancer | n/a | 1 [26] | Inadequate | No RCT; Only 1 cohort study was rated as having a moderate RoB |
Distal colon cancer | n/a | 1 [26] | Inadequate | No RCT; Only 1 cohort study was rated as having a moderate RoB |
Lung cancer | n/a | 2 [29,32] | Inadequate | No RCT; One cohort and one case-cohort cohort studies that were rated as having a moderate RoB showed inconsistent findings. |
Stomach cancer | n/a | 2 [34,37] | Inadequate | No RCT; One cohort and one case-cohort cohort studies that were rated as having a moderate RoB showed inconsistent findings. |
Prostate cancer | n/a | 1 [35] | Inadequate | No RCT; Only 1 cohort study was rated as having a moderate RoB |
Breast cancer | n/a | 1 [33] | Inadequate | No RCT; Only 1 cohort study rated as having a moderate RoB |
Hematologic malignancy | n/a | 1 [36] | Inadequate | No RCT; Only 1 cohort study was rated as having a moderate RoB |
SoE, strength of evidence; RCT, randomized controlled trial; RoB, risk of bias; n/a, not applicable.
1)The SoE grading scheme is presented in Supplementary Table 2.