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. 2021 Jul 26;15(6):773–788. doi: 10.4162/nrp.2021.15.6.773

Table 7. SoE grading: garlic intake by outcome1) .

Outcome No. of studies [Reference] SoE grade Explanation
RCTs Observational studies
Colorectal cancer 1 [24] 3 [29,30,31] Inadequate Only 1 RCT was rated as having a moderate RoB; Three cohort studies that were rated as having a moderate RoB presented inconsistent findings.
Colon cancer n/a 4 [25,26,27,28] Inadequate No RCT; Three cohort studies and one case-cohort studies that were rated as having a moderate RoB presented inconsistent findings.
Rectal cancer n/a 1 [27] Inadequate No RCT; Only 1 case-cohort study was rated as having a moderate RoB
Proximal colon cancer n/a 1 [26] Inadequate No RCT; Only 1 cohort study was rated as having a moderate RoB
Distal colon cancer n/a 1 [26] Inadequate No RCT; Only 1 cohort study was rated as having a moderate RoB
Lung cancer n/a 2 [29,32] Inadequate No RCT; One cohort and one case-cohort cohort studies that were rated as having a moderate RoB showed inconsistent findings.
Stomach cancer n/a 2 [34,37] Inadequate No RCT; One cohort and one case-cohort cohort studies that were rated as having a moderate RoB showed inconsistent findings.
Prostate cancer n/a 1 [35] Inadequate No RCT; Only 1 cohort study was rated as having a moderate RoB
Breast cancer n/a 1 [33] Inadequate No RCT; Only 1 cohort study rated as having a moderate RoB
Hematologic malignancy n/a 1 [36] Inadequate No RCT; Only 1 cohort study was rated as having a moderate RoB

SoE, strength of evidence; RCT, randomized controlled trial; RoB, risk of bias; n/a, not applicable.

1)The SoE grading scheme is presented in Supplementary Table 2.