Table 7.
Pathways regulated by the protein-protein interaction that were altered with rotenone and Yashtimadhu, after 48 h treatment.
| Interaction nodes | Confidence | Gene Ontology annotation | p-value | Corrected p-value | KEGG annotation | p-value | Corrected p-value |
|---|---|---|---|---|---|---|---|
| ERK1/2, PARP1, CASP3 | 0.96 | Cellular response to chemical stress | 3.0E-06 | 1.8E-03 | Apoptosis | 5E-06 | 4.7E-04 |
| ERK1, TP53, PHB, PDHA1 | 0.84 | Regulation of protein stability | 1.3E-05 | 3.7E-03 | Central carbon metabolism in cancer | 6.6E-07 | 2.0E-04 |
| ERK2, PARP1, ERK1, TP53, PHB, PDHA1 | 0.78 | Cellular response to oxidative stress | 3.2E-07 | 4.1E-04 | Central carbon metabolism in cancer | 2.8E-08 | 3.5E-05 |
| ERK2, PARP1, ERK1, TP53, PHB, HSPD1 | 0.78 | Response to oxidative stress | 1.7E-08 | 1.3E-04 | Apoptosis | 4.1E-07 | 1.5E-04 |
| ERK1/2, PARP1, PCNA | 0.96 | Cellular response to oxidative stress | 1.8E-06 | 1.3E-03 | Base excision repair | 5E-05 | 2.0E-03 |
| ERK1, PARP1, PCNA | 0.96 | Cellular response to oxidative stress | 1.8E-06 | 1.3E-03 | Base excision repair | 5E-05 | 2.0E-03 |
| ERK1/2, PARP1 | 0.96 | Cellular response to metal ion | 9.5E-05 | 1.3E-02 | Apoptosis | 2.9E-04 | 6.1E-03 |