Figure 6.

Specific recognition of the tumor sites by ¹¹CH₃-AS-14 proved by control experiments

(A–F) The representative PET/CT analysis of mice with tumor metastasis (I) using the ¹¹CH₃ primer (A) and ¹¹CH₃-unrelated aptamer (B) as probes. Metastasis formation was confirmed by autopsy (A2, B3). PET/CT images of physiological distribution and excretion of ¹¹CH₃-AS-14 (C) and ¹⁸F-FDG (E) in healthy mice (II). PET/CT image of a healthy mouse without the injected radiopharmaceutical (D). Histological examination with the staining of tissue sections with hematoxylin-eosin (F). Arrows indicate the tumor sites in different organs at PET/CT and autopsy.