Table 2.
Chemotherapeutic and surgical outcomes for included studies.
| NACT | PDS | Response to NACT | NACT patients receiving IDS | Extent of Debulking Surgery |
Additional Findings | ||
|---|---|---|---|---|---|---|---|
| n | n | n (%) | n (%) | NACT+IDS, n(%) | PDS, n(%) | ||
| Bogani et al., 2019 | 15 | 15 | NR | 15 (100) | 14 (93) complete 1 (7) optimal |
13 (87) complete 2 (13) optimal |
p = 0.96 for debulking outcomes • NACT arm with significantly shorter hospital stays (4 vs. 6d, p = 0.011) • NACT arm trend towards shorter op. time (127 vs. 177.6, p = 0.072) and trend towards lower transfusion rates (6.6% vs. 33.3%, p = 0.067) |
| de Lange et al., 2019 | 102 | – | 4 (4) CR 73 (72) PR 9 (9) SD 11 (11) PD 2 (2) died during treatment 3 (3) no imaging available |
80 (78) | 48 (60) complete 23 (29) optimal 9 (11) suboptimal |
– | |
| Eto et al., 2013 | 125 | 279 | 40 (68) CR/PR 9 (15) SD 7 (12) PD 3 (5) not evaluable •responses to NACT reported only for patients who received IDS |
59 (47) | 19 (32) complete 15 (25) optimal 25 (43) suboptimal |
61 (22) complete 65 (23) optimal 153 (55) suboptimal |
p = 0.087 for optimal cytoreduction |
| Holman et al., 2017 | 27 | 233 | 8 (30) CR 9 (33) PR/SD 10 (37) PD |
17 (63) | NR | NR | |
| Khouri et al., 2019 | 39 | – | 22 (56) PR 1 (3) SD 16 (41) PD |
16 (41) | 13 (81) complete/optimal 3 (19) suboptimal |
– | |
| Rajkumar et al., 2019 | 17 | 28 | NR | 17 (100) | NR | NR | |
| Tobias et al., 2020 | 952 | 3938 | NR | 555 (58) | NR | NR | |
| Vandenput et al., 2009 | 30 | – | 2 (7) CR 20 (67) PR 6 (20) SD 2 (7) PD |
24 (80) | 22 (92) complete 2 (8) optimal |
– | |
| Wilkinson-Ryan et al., 2015 | 10 | 34 | Average decline in CA 125 post-NACT = 91 ± 11% | 10 (100) | 7 (70) complete 3 (30) optimal |
11 (32) complete 17 (50) optimal 6 (18) suboptimal |
p = 0.10 for debulking outcomes •NACT arm with significantly shorter mean operative time (136.9 vs. 202.6 min., p = 0.025) and length of hospital stay (3 vs. 5 d., p = 0.0021) •NACT arm with trend towards less blood loss (410ml vs. 781.8ml, p = 0.063) |
CR = complete response, PR = partial response, SD = stable disease, PD = progressive disease, NR = not reported.