Table 1.
Association of the mRNA expression of MMPs with the prognosis of patients with colorectal cancer.
| MMPs | TCGA | GEO | ||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Overall survival (OS) | Disease-specific survival (DSS) | Progression-free survival (PFS) | Disease-free survival (DFS) | Relapse-free survival (RFS) | ||||||
| HR (95% CI) | p a | HR (95% CI) | p a | HR (95% CI) | p a | HR (95% CI) | p a | HR (95% CI) | p a | |
| MMP1 | 0.93 (0.83–1.05) | 2.73E−01 | 0.93 (0.77–1.11) | 4.15E−01 | 0.94 (0.84–1.05) | 2.74E−01 | 0.69 (0.51–0.92) | 1.35E−02 | 1.03 (0.98–1.09) | 2.29E−01 |
| MMP2 | 1.12 (0.92–1.36) | 2.46E−01 | 1.24 (0.92–1.65) | 1.53E−01 | 1.14 (0.95–1.37) | 1.56E−01 | 0.86 (0.57–1.31) | 4.90E−01 | 1.17 (1.06–1.29) | 1.38E−03 |
| MMP3 | 0.95 (0.85–1.06) | 3.74E−01 | 0.96 (0.82–1.13) | 6.44E−01 | 0.95 (0.85–1.05) | 2.76E−01 | 0.72 (0.56–0.93) | 1.30E−02 | 1 (0.94–1.06) | 9.62E−01 |
| MMP4 | 0.94 (0.35–2.49) | 8.99E−01 | 0.87 (0.23–3.22) | 8.30E−01 | 0.63 (0.27–1.49) | 2.95E−01 | 1.07 (0.18–6.43) | 9.39E−01 | – | – |
| MMP7 | 1.11 (0.98–1.27) | 9.83E−02 | 1.17 (0.97–1.41) | 1.10E−01 | 1.06 (0.94–1.18) | 3.63E−01 | 0.97 (0.75–1.25) | 8.16E−01 | 1.09 (1–1.18) | 5.36E−02 |
| MMP8 | 1.13 (0.98–1.31) | 1.04E−01 | 1.09 (0.89–1.33) | 4.07E−01 | 1.12 (0.99–1.27) | 7.52E−02 | 0.97 (0.71–1.33) | 8.55E−01 | 0.77 (0.64–0.92) | 4.84E−03 |
| MMP9 | 1.05 (0.89–1.24) | 5.66E−01 | 1.05 (0.82–1.33) | 7.11E−01 | 0.97 (0.84–1.14) | 7.42E−01 | 0.58 (0.37–0.91) | 1.71E−02 | 1.03 (0.93–1.14) | 5.35E−01 |
| MMP10 | 0.91 (0.8–1.03) | 1.43E−01 | 0.86 (0.72–1.04) | 1.30E−01 | 0.93 (0.83–1.05) | 2.21E−01 | 0.9 (0.69–1.17) | 4.28E−01 | 1.02 (0.91–1.14) | 7.44E−01 |
| MMP11 | 1.23 (1.01–1.49) | 3.71E−02 | 1.27 (0.96–1.69) | 9.37E−02 | 1.33 (1.11–1.59) | 2.15E−03 | 1.27 (0.83–1.94) | 2.63E−01 | 1.24 (1.09–1.42) | 1.71E−03 |
| MMP12 | 0.96 (0.83–1.11) | 5.72E−01 | 0.91 (0.74–1.13) | 3.97E−01 | 0.94 (0.82–1.07) | 3.59E−01 | 0.67 (0.48–0.94) | 2.08E−02 | 1.05 (0.99–1.1) | 9.10E−02 |
| MMP13 | 1.04 (0.92–1.17) | 5.72E−01 | 1.08 (0.91–1.28) | 3.79E−01 | 1.03 (0.92–1.15) | 6.25E−01 | 0.76 (0.57–1.01) | 5.43E−02 | 0.84 (0.73–0.97) | 1.40E−02 |
| MMP14 | 1.36 (0.99–1.86) | 5.43E−02 | 1.73 (1.11–2.68) | 1.44E−02 | 1.38 (1.04–1.82) | 2.47E−02 | 1.01 (0.54–1.9) | 9.69E−01 | 1.47 (1.15–1.89) | 2.48E−03 |
| MMP15 | 0.89 (0.53–1.49) | 6.53E−01 | 0.92 (0.44–1.9) | 8.14E−01 | 1.04 (0.66–1.66) | 8.56E−01 | 1.63 (0.59–4.55) | 3.49E−01 | 0.99 (0.85–1.16) | 8.95E−01 |
| MMP16 | 1.28 (1.02–1.62) | 3.66E−02 | 1.49 (1.06–2.1) | 2.08E−02 | 1.25 (1.01–1.56) | 4.03E−02 | 1 (0.59–1.69) | 9.94E−01 | 0.88 (0.81–0.95) | 1.97E−03 |
| MMP17 | 1.24 (1.04–1.49) | 1.97E−02 | 1.41 (1.06–1.87) | 1.84E−02 | 1.19 (1.01–1.41) | 3.91E−02 | 1.36 (0.9–2.06) | 1.49E−01 | 1.48 (1.14–1.92) | 3.01E−03 |
| MMP19 | 1.92 (1.28–2.88) | 1.51E−03 | 1.9 (1.08–3.32) | 2.51E−02 | 1.48 (1.03–2.13) | 3.47E−02 | 1.15 (0.56–2.38) | 6.97E−01 | 1.31 (1.16–1.49) | 2.35E−05 |
| MMP20 | 1 (0.74–1.37) | 9.83E−01 | 0.87 (0.55–1.38) | 5.61E−01 | 0.94 (0.72–1.23) | 6.47E−01 | 0.65 (0.34–1.23) | 1.83E−01 | 0.67 (0.51–0.9) | 6.96E−03 |
| MMP21 | 1.44 (0.8–2.58) | 2.25E−01 | 1.19 (0.45–3.12) | 7.29E−01 | 0.9 (0.49–1.66) | 7.47E−01 | 1.37 (0.4–4.71) | 6.17E−01 | 0.54 (0.26–1.12) | 9.95E−02 |
| MMP23a | 1.12 (0.75–1.69) | 5.76E−01 | 0.86 (0.48–1.56) | 6.23E−01 | 1.01 (0.69–1.48) | 9.71E−01 | 1.59 (0.62–4.07) | 3.29E−01 | – | − |
| MMP23b | 1.72 (1.26–2.35) | 6.96E−04 | 1.64 (1.03–2.59) | 3.52E−02 | 1.4 (1.06–1.86) | 1.91E−02 | 1.12 (0.59–2.12) | 7.24E−01 | – | − |
| MMP24 | 1.11 (0.72–1.69) | 6.43E−01 | 0.57 (0.31–1.05) | 7.28E−02 | 0.85 (0.58–1.25) | 4.19E−01 | 1.24 (0.46–3.34) | 6.75E−01 | 1.67 (1.24–2.25) | 8.48E−04 |
| MMP25 | 0.87 (0.68–1.12) | 2.91E−01 | 0.95 (0.66–1.39) | 8.08E−01 | 0.82 (0.65–1.03) | 8.39E−02 | 0.61 (0.34–1.09) | 9.51E−02 | 1.25 (0.98–1.59) | 6.65E−02 |
| MMP26 | 1.4 (0.54–3.67) | 4.91E−01 | 1176.9 (0–0) | 1.00E+00 | 0.61 (0.17–2.14) | 4.40E−01 | 0.02 (0–17787.09) | 5.71E−01 | 1.25 (0.77–2.02) | 3.73E−01 |
| MMP27 | 0.65 (0.2–2.18) | 4.89E−01 | 0.6 (0.08–4.71) | 6.29E−01 | 1.19 (0.71–2) | 5.00E−01 | 0.02 (0–42.44) | 3.28E−01 | 0.48 (0.3–0.77) | 2.43E−03 |
| MMP28 | 0.97 (0.81–1.16) | 7.65E−01 | 1.05 (0.8–1.37) | 7.24E−01 | 1.09 (0.92–1.28) | 3.30E−01 | 0.94 (0.65–1.37) | 7.62E−01 | 1.57 (1.19–2.07) | 1.52E−03 |
a
Age at diagnosis and sex were adjusted by using multivariate Cox regression. Records with a p<0.05 were bolded. MMP11, MMP14, MMP17 and MMP19 were bolded because they were positively associated with CRC prognosis both in the PFS and in the RFS analyses.