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. 2021 Nov 5;11:761074. doi: 10.3389/fcimb.2021.761074

Figure 5.

Figure 5

CXCL16 interaction network. (A) Physical network of CXCL16 indicating physical protein associations. Colours present five of the most upregulated KEGG pathways (strength > 2, FDR < 5.94e-21): Red = GABAergic synapse (hsa04727), yellow = serotonergic synapse (hsa04726), purple = cholinergic synapse (hsa04725), blue = glutamatergic synapse (hsa04724), green = dopaminergic synapse (hsa04728) (B) Full network of CXCL16 indicating functional and physical protein associations. Colours present four of the most upregulated biological processes from gene ontology (strength > 2, FDR < 0.00021): Red = T cell chemotaxis (GO:0010818), blue = regulation of T cell chemotaxis (GO:0010819), green = macrophage chemotaxis (GO:0048246), yellow = positive regulation of monocyte chemotaxis (GO:0090026). Networks were generated by using the STRING version 11.0. GNB, beta unit of guanine nucleotide-binding proteins; GNG, gamma unit of guanine nucleotide-binding proteins.