Table 4.
Mean (standard deviation) central corneal endothelial cell density in study eyes by specular microscopy, cells/mm2 (safety population)
| Visit | Bimatoprost implant 10 µg (n = 175) |
Bimatoprost implant 15 µg (n = 176) |
Timolol BID (n = 173) |
All fellow eyes (n = 524) |
P Valuea Bim 10 µg vs. Timolol |
P Valuea Bim 15 µg vs. Timolol |
|---|---|---|---|---|---|---|
| Baseline | 2435.6 (311.2) | 2487.7 (301.9) | 2469.2 (355.1) | 2437.1 (346.2) | – | – |
| Week 12 | 2425.4 (319.4) | 2462.0 (310.8) | 2448.8 (343.5) | 2428.7 (359.4) | 0.027 | 0.791 |
| Week 28 | 2411.2 (327.3) | 2411.5 (354.5) | 2453.9 (355.3) | 2427.4 (361.5) | 0.280 | < 0.001 |
| Week 44 | 2382.9 (366.9) | 2309.6 (504.0) | 2461.2 (361.6) | 2431.0 (372.3) | 0.188 | < 0.001 |
| Week 52 | 2355.0 (404.0) | 2237.9 (557.5) | 2437.1 (372.6) | 2420.1 (375.5) | 0.059 | < 0.001 |
| Month 20 | 2303.6 (454.1) | 2091.6 (638.9) | 2451.5 (375.5) | 2418.1 (369.8) | 0.001 | < 0.001 |
BID twice daily, Bim bimatoprost implant
aP values are based on a mixed-effect model for repeated measures including treatment, visit, treatment-by-visit interaction, baseline central corneal endothelial cell density, and visit-by-baseline interaction