Table 2.

Multivariable Cox regression analyses predicting survival outcomes

	OS			CSS			PFS			RFS
	Multivariable			Multivariable			Multivariable			Multivariable
	HR	(95% CI)	P value	HR	(95% CI)	P value	HR	(95% CI)	P value	HR	(95% CI)	P value
Age (ref. ≤ 70)
> 70	3.13	2.48–3.96	< 0.001	1.99	1.12–3.54	0.019	1.89	1.27–2.81	0.002	1.72	1.43–2.08	< 0.001
Sex	0.74	0.56–0.99	0.045	0.78	0.40–1.54	0.47	1.06	0.68–1.65	0.81	0.94	0.76–1.17	0.60
Smoking	0.92	0.70–1.20	0.52	1.79	0.80–4.01	0.16	1.96	1.11–3.46	0.020	1.10	0.88–1.37	0.40
Adjuvant BCG	0.79	0.58–1.09	0.16	0.84	0.43–1.65	0.62	0.69	0.43–1.13	0.14	0.84	0.67–1.05	0.12
Concomitant CIS	0.99	0.52–1.86	0.97	0.97	0.31–2.98	0.95	0.97	0.42–2.21	0.94	0.88	0.58–1.34	0.55
Number of tumor (ref. < 8)
8 ≤	1.67	1.11–2.52	0.014	2.80	1.34–5.85	0.006	2.14	1.25–3.67	0.006	1.03	0.73–1.45	0.87
Tumor size (ref. < 3)
3 ≤	1.10	0.84–1.41	0.51	0.92	0.51–1.67	0.78	1.06	0.70–1.61	0.78	2.38	1.96–2.88	< 0.001
Prior recurrence rate (ref. Primary, ≤ 1 recurrence/yr)
1 < recurrence/yr										1.09	0.76–1.55	0.65
Grade (ref. Grade 1)
Grade 2	1.29	0.93–1.76	0.13	11.6	1.54–87.0	0.017	2.49	1.15–5.42	0.021	1.74	1.33–2.29	< 0.001
Grade 3	1.57	0.79–3.12	0.20	42.7	4.99–366.3	0.001	8.83	3.37–23.1	< 0.001	2.50	1.58–3.95	< 0.001
Stage (ref. pTa, Tis)
pT1	0.77	0.40–1.46	0.42	0.36	0.15–0.90	0.03	0.42	0.21–0.83	0.013	0.42	0.28–0.63	< 0.001
SII	1.04	0.80–1.36	0.78	2.53	1.42–4.48	0.001	1.84	1.23–2.77	0.003	1.23	1.00–1.50	0.046
C-index without SII	0.66			0.75			0.71			0.66
C-index with SII	0.67			0.78			0.74			0.66

Bold P values are considered statistically significant

BCG bacillus Calmette–Guerin, CIS carcinoma in situ, SII systemic inflammatory index, OS overall survival, CSS cancer-specific survival, PFS progression-free survival, RFS recurrence-free survival