Table 4.
Multiple linear regression models investigating associations between the neurocognitive tests and Ov16 status
| Model No | Covariates | Adjusted regression coefficient (95% CI) | P-Value | Model No | Covariates | Adjusted regression coefficient (95% CI) | P-Value | Model No | Covariates | Adjusted regression coefficient (95% CI) | P-value |
|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 (DV average Pegboard score) | Ov16-positive test | 0.06 (− 0.21 to 0.33) | 0.660 | 2 (DV average Digit span score) | Ov16-positive test | − 0.02 (− 0.29 to 0.26) | 0.907 | 3 (DV hand movements) | Ov16-positive test | − 0.05 (− 0.33 to 0.22) | 0.705 |
| Female gender | 0.02 (− 0.24 to 0.29) | 0.860 | Female gender | − 0.11 (− 0.38 to 0.16) | 0.428 | Female gender | − 0.35 (− 0.62 to − 0.78) | 0.012 | |||
| Previous IVM 0 | 0.44 (–21 to 1.08) | 0.182 | Previous IVM 0 | 0.92 (0.26 to 1.57) | 0.006 | Previous IVM 0 | 0.71 (0.06 to 1.36) | 0.032 | |||
| Previous IVM 1–2 × | 0.06 (–0.54 to 0.66) | 0.840 | Previous IVM 1–2 × | 0.63 (0.02 to 1.24) | 0.044 | Previous IVM 1–2 × | 0.38 (− 0.23 to 0.99) | 0.219 | |||
| Previous IVM 3–5 × | 0.40 (–0.24 to 1.04) | 0.215 | Previous IVM 3–5 × | 0.58 (− 0.07 to 1.23) | 0082 | Previous IVM 3–5 × | 0.50 (− 0.14 to 1.15) | 0.126 | |||
| Previous IVM > 5 × | 0.30 (–0.53 to 1.13) | 0.471 | Previous IVM > 5 × | 0.58 (− 0.26 to 1.43) | 0.176 | Previous IVM > 5 × | 0.80 (− 0.04 to 1.64) | 0.061 | |||
| Education: primary | 2.02 (0.67 to 3.37) | 0.004 | Education: primary | 0.64 (− 0.74 to 2.01) | 0.363 | Education: primary | 1.19 (− 0.18 to 2.55) | 0.088 | |||
| Education: secondary | 2.09 (0.66 to 3.52) | 0.004 | Education: secondary | 1.18 (− 0.28 to 2.64) | 0.113 | Education: secondary | 1.28 (− 0.17 to 2.73) | 0.082 | |||
| BMI-for-age z-score | –0.08 (–0.19 to 0.03) | 0.142 | BMI-for-age z-score | 0.08 (− 0.03 to 0.20) | 0.154 | BMI-for-age z-score | 0.08 (− 0.04 to 0.19) | 0.176 | |||
| Height-for-age z-score | 0.13 (0.02 to 0.24) | 0.020 | Height-for-age z-score | 0.06 (− 0.05 to 0.18) | 0.260 | Height-for-age z-score | 0.10 (− 0.01 to 0.21) | 0.079 | |||
| 4 (DV semantic verbal fluency) | Ov16-positive test | − 0.38 (− 0.65 to − 0.11) | 0.006 | 5 (DV MMSE) | Ov16-positive test | − 0.21 (− 0.48 to 0.06) | 0.123 | 6 (DV IHDS) | Ov16-positive test | − 0.31 (− 0.56 to − 0.04) | 0.025 |
| Female gender | − 0.10 (− 0.37 to 0.16) | 0.442 | Female gender | − 0.14 (− 0.41 to 0.12) | 0.287 | Female gender | − 0.04 (− 0.30 to 0.23) | 0.777 | |||
| Previous IVM 0 | 0.72 (0.08 to 1.36) | 0.028 | Previous IVM 0 | 0.76 (0.11 to 1.40) | 0.021 | Previous IVM 0 | 0.45 (− 0.19 to 1.09) | 0.165 | |||
| Previous IVM 1–2 × | 0.47 (− 0.13 to 1.08) | 0.121 | Previous IVM 1–2 × | 0.64 (0.04 to 1.24) | 0.036 | Previous IVM 1–2 × | 0.60 (0.01 to 1.20) | 0.048 | |||
| Previous IVM 3–5 × | 0.65 (0.01 to 1.29) | 0.046 | Previous IVM 3–5 × | 0.70 (0.06 to 1.34) | 0.032 | Previous IVM 3–5 × | 0.76 (0.13 to 1.40) | 0.019 | |||
| Previous IVM > 5 × | 1.27 (0.44 to 2.10) | 0.003 | Previous IVM > 5 × | 1.05(0.22 to 1.88) | 0.013 | Previous IVM > 5 × | 1.39 (0.56 to 2.21) | 0.001 | |||
| Education: primary | 1.61 (0.26 to 2.95) | 0.019 | Education: primary | 1.46 (0.11 to 2.81) | 0.033 | Education: primary | 0.95 (− 0.39 to 2.29) | 0.114 | |||
| Education: secondary | 2.01 (0.59 to 3.44) | 0.006 | Education: secondary | 1.90 (0.47 to 3.33) | 0.009 | Education: secondary | 1.14 (− 0.28 to 2.57) | ||||
| BMI-for-age z-score | − 0.02 (− 0.13 to 0.09) | 0.727 | BMI-for-age z-score | − 0.00 (− 0.11 to 0.11) | 0.999 | BMI-for-age z-score | 0.05 (− 0.06 to 0.16) | 0.406 | |||
| Height-for-age z-score | 0.01 (− 0.10 to 0.12) | 0.802 | Height-for-age z-score | 0.16 (0.05 to 0.27) | 0.004 | Height-for-age z-score | 0.16 (0.05 to 0.27) | 0.004 |
DV dependent variable, IVM ivermectin