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. 2021 Nov 18;12:6714. doi: 10.1038/s41467-021-27051-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 1 — Blue dots indicate dihydroartemisinin-piperaquine (DP) courses dispensed, and dashes indicate episodes when a placebo was given. The red dots indicate sparse pharmacokinetic (PK) sampling for piperaquine concentrations (all participants contributed data) and red lines indicate typical pharmacokinetic profiles. Intensive sampling, in orange dots, occurred at 32 and 104 weeks (22 individuals in every 12 weeks and 10 in the every 4 weeks arm).