Table 5.

Studies assessing cone location as a predictor of outcomes following cross-linking.

Author	Eyes/pts	Population	aTwo eye stats	MVA	Methodology	Protocol	Cone location and main outcomes
Greenstein et al. [8]	104/NA	KC, ectasia	NA	Yes	Prospective	30 min	No association with main outcomes.
Toprak et al. [5]	99/99	KC	1 eye per patient	No	Retrospective	30 min	No association with main outcomes.
Wisse et al. [9]	102/79	KC	Adjusted statistics	Yes	Prospective	30 min	Eccentricity associated with Kmax outcome. Visual outcome not associated with eccentricity.
Koc et al. [10]	162/146	KC	No adjustment	Yes	Retrospective	10 min	No association with main outcomes.
Sarac et al. [11]	72/52	Pediatric KC	No adjustment	Yes	Retrospective	30 min	Eccentricity associated with Kmax outcome.
Mimouni et al.	314/314	KC	1 eye per patient	Yes	Prospective	10 min	No association with Kmax outcome. Eccentricity associated with visual outcome. Eccentricity associated with myopia reduction.

Pts patients, KC keratoconus, MVA multivariate analysis, NA not available.

^aTwo eye stats—how authors dealt with two eyes per patient in statistical analyses.