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. 2021 Nov 18;12:6704. doi: 10.1038/s41467-021-26871-y

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 2 — a Combined analysis pipeline for validating cases of degron loss in fusion genes. Created with BioRender.com. b Enrichment for in-frame gene fusions for oncogenes and tumor suppressor genes relative to likely passenger genes (STAR methods). Recurrence is the number of tumors that a fusion gene was present in the TCGA. Barplot displays the log odds ratio (LOR), with error bars indicating ±1 SE. In order of bars from left to right, sample sizes (i.e. number of fusions) are n = 17,848, n = 4254, n = 1316, n = 17,581, n = 3,799, and n = 925. A two-sided Fisher’s exact test was performed. c Enrichment analysis for whether gene fusions result in the retention of at least one protein domain from the original protein sequence. Barplot displays the log odds ratio (LOR), with error bars indicating ±1 SE. In order of bars from left to right, sample sizes (i.e. number of fusions) are n = 8911, n = 9139, n = 8935, and n = 8896. A two-sided Fisher’s exact test was performed. d The total number of tumors in the TCGA that contain highly recurrent fusion genes (a fusion found in >10 tumors). e Balance of degron gain and loss in oncogene, tumor suppressor genes or passenger genes. f The top 10 most significant oncogenes that are biased towards loss of internal degrons in gene fusions. g Network diagram showing degron loss in the fusion partners to oncogene RET. Line width represents the frequency of the event. Red indicates previously annotated oncogenes. Numbers indicate the recurrence of the fusion across TCGA. The relevant raw data are provided in Source Data.