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. 2021 Nov 18;10:233. doi: 10.1038/s41377-021-00674-8

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a–e Violin plots show quantitative comparisons of the statistical distribution of the measured nuclear morphological parameters between the acetic acid virtually stained skin tissue images (blue) and their corresponding ground truth images obtained using actual acetic acid staining (orange). Five metrics are used for the comparison: a nuclear size, b contrast, c eccentricity, d concentration, and f compactness (see Materials and Methods for details). The statistical results cover a total number of 96,731 nuclei, detected in 176 ex vivo tissue images of normal skin. f, g Violin plot shows the statistical distribution of the PCC and SSIM values measured through comparing the virtually stained (acetic acid) tissue images against their corresponding actual acetic acid-stained ground truth images. In all the violin plots presented above, the dashed lines from top to bottom represent the 75, 50 (median), and 25 quartiles, respectively.