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. 2021 Nov 18;11:22520. doi: 10.1038/s41598-021-01905-z

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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(a) Annotation: Annotated image, corresponding magnified image (above), and Dashed red line profiles (below). (b) Small ROI: The result of small ROI input in spatial domain (Tile size: 256 by 256, ×20 magnification). (c) Low resolution: The result of low-resolution input in spatial domain (Tile size: 512 by 512, ×10 magnification). (d) Standard: The result of standard input in spatial domain (Tile size: 512 by 512, ×20 magnification). (e) GRAY-DWT (WAE): The result of weighted average ensemble (WAE) result for wavelet sub-band after grayscale conversion. (f) GRAY-DWT (WWE): The result of wavelet weighted ensemble (WWE) result for wavelet sub-band after grayscale conversion. (g) PCA-DWT (WAE): The result of weighted average ensemble (WAE) result for wavelet sub-band after principle component analysis (PCA). (f) PCA-DWT (WWE): The result of wavelet weighted ensemble (WWE) result for wavelet sub-band after principal component analysis (PCA).