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. 2021 Nov 18;12:6686. doi: 10.1038/s41467-021-26963-9

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 8 — a–h Macroscopic phenotype of mice where dots, lines, and error bars represent, respectively, individual mice, means, and SEM. Female (F) and male (M), breeding diet (BD), and depleted diet (DD), respectively. a, e Body weight or size curves and mean daily gain of animals in facility 2. One-way ANOVA followed by Tukey’s multiple comparison analyses (GM15 mice: 9 F, 9 M_BD, 11 M_DD; SPF mice: 12 F, 12 M_BD, 13 M_DD; Oligo-MM¹² mice: 9 F, 8 M_BD, 9 M_DD). b, f Mean daily body weight and size gain comparison between GM15 and SOPF/SPF mice in facilities 1 (GM15 mice: 9 F, 10 M_BD, 9 M_DD; SOPF mice: 10 F, 10 M_BD, 10 M_DD) and 2 (GM15 mice: 9 F, 9 M_BD, 11 M_DD; SPF mice: 12 F, 12 M_BD, 13 M_DD). One-way ANOVA followed by Tukey’s multiple comparison analyses. c, g One-way ANOVA analyses of femur and tibia length of animals in facility 2. One-way ANOVA followed by Dunn’s and Tukey’s multiple comparison analyses for F and M data sets, respectively (GM15 mice: 9 F, 9 M_BD, 11 M_DD; SPF mice: 12 F, 12 M_BD, 13 M_DD; Oligo-MM¹² mice: 9 F for femur and 8 F for tibia, 8 M_BD, 9 M_DD). d, h Serum IGF-1 and IGFB3 of animals at day 56 in facility 2. One-way ANOVA followed by Tukey’s multiple comparison analyses (GM15 mice: 9 F, 9 M_BD, 10 M_DD; SPF mice: 10 F, 12 M_BD, 12 M_DD; Oligo-MM¹² mice: 9 F, 8 M_BD, 9 M_DD). *P < 0.05, **P < 0.01, ***P < 0.001, ****P < 0.0001. Source data are provided as a Source Data file.