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. 2021 Nov 5;12:663655. doi: 10.3389/fphar.2021.663655

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Copyright © 2021 Vörös, Sághy, Pohóczky, Makkos, Onódi, Brenner, Baranyai, Ágg, Váradi, Kemény, Leszek, Görbe, Varga, Giricz, Schulz, Helyes and Ferdinandy.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Top thirty Gene Ontology (GO) biological process terms significantly enriched among the mRNAs (n = 143) differentially expressed in the comparison between remote ischemic conditioning (RIC) and ischemia/reperfusion (I/R) groups in the order of decreasing fold enrichment values. GO enrichment analysis highlights the effect of RIC on skeletal muscle fiber development, muscle tissue regeneration, cardiac muscle cell differentiation, superoxide metabolic processes, reactive oxygen species metabolic processes, and response to oxidative stress. Adjusted Fisher’s exact p values were <0.05 in case of each shown process after false discovery rate adjustment for multiple comparisons.