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. 2021 Jun 14;35(12):3202–3221. doi: 10.1038/s41433-021-01595-x

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© The Author(s) 2021

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a The first-generation iStent^®, showing its self-trephining tip that is inserted into Schlemm’s canal via a sideways sliding technique, its retention arches which help maintaining the device in position, and its lumen that faces the anterior chamber [68]; image courtesy of Glaukos Corporation. b The second-generation iStent inject^®, showing its head containing four side ports and designed to fit into Schlemm’s canal, and its flange with an inlet lumen that faces the anterior chamber as illustrated in the figure on the right side [68, 74]; images courtesy of Glaukos Corporation. c The iStent inject^® W, showing its larger flange diameter as compared with the previous version iStent inject^® [79]; image courtesy of Glaukos Corporation. d The Hydrus^® Microstent, showing its three open windows along its anterior surface and its placement in the eye (figure on the right) [75, 76]; images courtesy of Ivantis Inc.