Figure 6.

RPE subpopulations contribute to paracrine signalling

UMAP of single-cell expression profile of markers for 1-month-old and 12-month-old cultures, with associated violin plots, representing Log₂ UMI counts across all populations for CCL2 (A); SFRPs, FZDs, and WNTS (B); VEGFA (C); APOE, LDLR, and LRPs (D). In the UMAPs, the intensity of gene expression is indicated by colour gradient. UMAP of single-cell expression profile of markers for 1-month-old and 12-month-old cultures, with associated violin plots across all populations for CCL2 (A), SFRP1 (B), SFRP2 (C), SFRP5 (D), FZD1 (E), FZD8 (F), WNT2B (G), WNT3 (H), WNT4 (I), WNT5A (J), VEGFA (K), APOE (L), LDLR (M), LRP1 (N), LRP2 (O), LRP8 (P). In the UMAP plots, the intensity of gene expression is indicated by colour gradient. In the violin plots, different colours are used for each subpopulation for ease of reading.