Supplementary figure S2.

Characterisation of stable cell subpopulations. Graph-based clustering was performed at different resolutions ranging from 0 to 1.5, in increments of 0.1 for 1-month-old (A), 12-month-old (B), and combined (C) datasets using clustree. Regions of stability are represented by minimal branching. Values within circles are arbitrary cluster identifiers and arrows indicate the proportion of cells moving from one group to another (transitioning cells, colour coded). D. Integration of clusters identified in 1-month-old and 12-month-old cells via MetaNeighbor. Heatmap represents degree of similarity of clusters as AUROC values. AUROC, area under receiver operating characteristic curve.