Figure 1.

Landscape of immune cells from peripheral blood and decidual tissues at early pregnancy

A. UMAP plot of scRNA-seq data to show the 22 leukocyte clusters in peripheral blood and decidual tissues at early pregnancy from both Ctrl and RM patients. B. UMAP plot showing cell populations from peripheral blood and decidual tissue from both Ctrl and RM patients. C. UMAP visualization of cell clustering in Ctrl (top) and RM (bottom) pregnancies. D. Cell type annotation of the 22 leukocyte clusters based on the expression of their canonical marker genes. Ctrl, normal; RM, recurrent miscarriage; B, peripheral B cell; CD4T naive, peripheral CD4⁺ naive T cell; CD8T naive, peripheral CD8⁺ naive T cell; MAIT, peripheral mucosal-associated invariant T cell; CD4T memory, peripheral CD4⁺ memory T cell; CD8T effector, CD8⁺ T effector cell; NK dim, peripheral CD56^dimCD16⁺ NK cell; NK bright, peripheral CD56^bright CD16⁻ NK cell; CD14 mono, peripheral CD14⁺ monocyte; CD16 mono, peripheral CD16⁺ monocyte; DC, dendritic cell; dNK, decidual natural killer cell; dCD4, decidual CD4⁺ T cell; dCD8, decidual CD8⁺ T cell; dTreg, decidual regulatory T cell; dM, decidual macrophage; ILC3, group 3 innate lymphoid cell.