Figure 4.
Molecular annotation of human dNK subtypes
A. Heatmap showing the relative expression of the top marker genes defining the 5 dNK subsets. The top 20 genes for each subset are defined using the method of non-parametric two-sided Wilcoxon rank sum test in Seurat, and typical marker genes for each subset are indicated om the right. B. KEGG enrichment analysis using differential genes (log2 FC > 0.5 and Bonferroni-adjusted P < 0.05) from the five dNK subsets to illustrate the functional signature of these cells. The differential expression analyses is performed using the method of non-parametric two-sided Wilcoxon rank sum test in Seurat. C. Heatmap showing the expression of genes encoding receptors for HLA antigens in dNK subsets. HLA, human leukocyte antigen.